• Internal medicine · Oct 2022

    Case Reports

    Combination Immunosuppressive Therapy for Giant Cell Myocarditis: A Case Report.

    • Takashi Funaki, Mike Saji, Tatsuya Murai, Ryosuke Higuchi, Mamoru Nanasato, and Mitsuaki Isobe.
    • Department of Cardiology, Sakakibara Heart Institute, Japan.
    • Intern. Med. 2022 Oct 1; 61 (19): 2895-2898.

    AbstractA 60-year-old woman with a history of hypothyroidism was referred to our hospital for shortness of breath and a left ventricular ejection fraction (LVEF) of 13%, which required continuous dobutamine injection with intra-aortic balloon pump support. An endomyocardial biopsy obtained from the right ventricle revealed an infiltration of giant cells and eosinophils, indicating giant cell myocarditis. In addition to heart failure treatment, combined immunotherapy with steroids, tacrolimus, and intravenous immunoglobulin was administered. Transthoracic echocardiography demonstrated a dramatic improvement in the LVEF after this therapy, and the patient was discharged home without symptoms on day 72.

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