• Dongfeng Zhang.
• Dongfeng Zhang, Neurology Department, Henan Provincial People's Hospital, Henan, 450000, China.
• Pak J Med Sci. 2017 Sep 1; 33 (5): 1065-1069.

ObjectiveTo discuss the roles of magnetic resonance imaging (MRI) and cerebrospinal fluid analysis in the identification of central nervous system associated infection and provide a reference for the diagnosis and treatment of central nervous system associated infectious diseases.MethodsSeventy-six patients who developed central nervous system infection and were admitted into the Henan People's Hospital between June 2014 and October 2015 were randomly selected as an observation group. Patients in the observation group were subdivided according to purulent meningitis, cryptococcal meningitis, viral meningitis and tubercular meningitis. Moreover, 35 headache patients who were admitted in the same period were selected as a control group. The MRI results and cerebrospinal fluid examination indicators were compared between the two groups.ResultsMRI results suggested that the positive rate of the observation group was 96.05% (73/76), much higher than 8.57% in the control group (3/35), and the difference had statistical significance (P<0.05). The analysis results of cerebrospinal fluid demonstrated that the concentration of lactate dehydrogenase (LDH) in the cerebrospinal fluid of the patients with tubercular meningitis was the highest, the concentration of creatine kinase (CK) in the cerebrospinal fluid of the patients with purulent meningitis was the highest, and the concentration of lactic acid (LA) in the cerebrospinal fluid of the patients with tubercular meningitis and purulent meningitis was higher than that of the other patients; the differences were statistically significant (P<0.05). The analysis on the diagnostic efficacy of MRI in combination with cerebrospinal fluid analysis suggested that the sensitivity of the diagnostic scheme was high in diagnosing meningitis except purulent meningitis, and the specificity and accuracy of the scheme was high in diagnosing meningitis except cryptococcal meningitis.ConclusionMRI in combination with cerebrospinal fluid analysis is effective in diagnosing central nervous system associated infectious diseases. It can also effectively identify the types of infection besides improving accuracy, which provides an important reference for clinical treatment.

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