• Carol L Hodgson, Alisa M Higgins, Michael J Bailey, Anne M Mather, Lisa Beach, Rinaldo Bellomo, Bernie Bissett, Ianthe J Boden, Scott Bradley, Aidan Burrell, D James Cooper, Bentley J Fulcher, Kimberley J Haines, Isabelle T Hodgson, Jack Hopkins, JonesAlice Y MAYMSchool of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Queensland, Australia., Stuart Lane, Drew Lawrence, Lisa van der Lee, Jennifer Liacos, Natalie J Linke, Lonni Marques Gomes, Marc Nickels, George Ntoumenopoulos, Paul S Myles, Shane Patman, Michelle Paton, Gemma Pound, Sumeet Rai, Alana Rix, Thomas C Rollinson, Claire J Tipping, Peter Thomas, Tony Trapani, Andrew A Udy, Christina Whitehead, Shannah Anderson, NetoAry SerpaASAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine.Department of Critical Care, School of Medicine, and.Data Analytics Research and Evaluation (DARE) Centre, Austin Hospital, Melbourne, and COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group.
• Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine.
• Am. J. Respir. Crit. Care Med. 2022 May 15; 205 (10): 115911681159-1168.

AbstractRationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19. Methods: We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age ⩾ 8 yr) and received ⩾24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P = 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P = 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [66/0%]; P = 0.583). Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19. Clinical trial registered with www.clinicaltrials.gov (NCT04401254).

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