• Presse Med · Jun 1998

    Review

    [Nitric oxide (NO), vascular protection factor. Biology, physiological role and biochemistry of NO].

    • A Tiritilli.
    • Laboratoire de Physiologie et Pharmacologie cardiovasculaire, Centre Hospitalier, Saint-Germain-en-Laye.
    • Presse Med. 1998 Jun 13; 27 (21): 1061-4.

    AbstractVASOMOTRICITY: The vascular endothelium plays a key role in vasomotricity by producing a number of factors which modulate smooth muscle relaxation and contraction. Nitric oxide (NO) has been found to be one of the most important relaxation factors. NO SYNTHESIS: Nitric oxide is synthesized from L-arginine by NO-synthetase whose activity is regulated by intracellular calcium concentration and modulated by pharmacological compounds such as acetylcholine, 5-hydroxytryptamine, bradykinin and ADP as well as the sheer forces produced by blood flow.

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