-
- A Tiritilli.
- Laboratoire de Physiologie et Pharmacologie cardiovasculaire, Centre Hospitalier, Saint-Germain-en-Laye.
- Presse Med. 1998 Jun 13; 27 (21): 1071-2.
AbstractAGING PROCESS: There is a large body of experimental and clinical data demonstrating that endothelial dysfunction is encountered not only in disease states such as atherosclerosis, hypertension, heart failure or diabetes, but also in the normal physiological process of aging. Currently available data show that endothelium-dependent function declines with age. The fact that this same decline is observed in patients with hypertension suggests that age is an independent factor capable of provoking changes in the vascular endothelium. CAUSAL MECHANISMS: It is often suggested that altered NO synthesis from L-arginine and/or increased production of contraction factors play a role in the aggravation of endothelial and parietal lesions and would thus affect the natural history of the disease process.
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