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- N Ortonne and J P Ortonne.
- Service d'Anatomo-Pathologique, Pr. Janin, Hôpital Saint-Louis, Paris. ortonne@unice.fr
- Presse Med. 1999 Jun 26; 28 (23): 1259-65.
AbstractA MULTIFACTORIAL ORIGIN: Psoriasis is an inflammatory dermatosis resulting from abnormal epidermal homeostatis and characterized by hyperproliferation and abnormal keratinocyte differentiation as well as activation of the skinis immune system. This dermatosis is a prototype of multifactorial conditions implicating hereditary and environmental pathogenic mechanisms. TWO TYPES OF PSORISASIS: Familial psoriasis is observed early in life and is strongly associated with the major histocompatibility complex, particularly CW6, DR7, B1, and B57 molecules. The sporadic non-familial form develops later in life.
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