• Presse Med · Apr 2000

    Review

    [Role of matrix metalloproteinases in the progression of renal lesions].

    • H P Marti.
    • Département de Médecine, Inselspital Bern, Suisse.
    • Presse Med. 2000 Apr 15; 29 (14): 811-7.

    AbstractMETALLOPROTEINASES: The progression to end-stage kidney disease is accompanied by accumulation of extracellular matrix (ECM) proteins. The degradation of ECM proteins occurs by the action of proteases, notably the matrix metalloproteinases (MMP). MMP can be classified into four major groups, such as interstitial collagenases, gelatinases, stromelysins, and membrane-type (MT)-MMP. MMP are also involved in the regulation of cell proliferation and possibly of apoptosis. In the kidney, MMP are synthesized by intrinsic glomerular cells and tubular epithelial cells.

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