• Presse Med · Dec 2000

    [Resistance to protease inhibitors: the role of the MDR gene].

    • F Raffi.
    • Service Maladies infectieuses et tropicales, CHU Hôtel Dieu, Nantes.
    • Presse Med. 2000 Dec 2; 29 (37): 2036-7.

    AbstractMDR GENES: Overexpression of MDR genes leads to the production of glycoprotein P (PGP) that can use protease inhibitors as a substrate. This overexpression of MDR genes appears to be the cause, at least partially, of resistance to protease inhibitors by induction of very low intracellular inhibitor concentrations.

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