• Presse Med · Jan 2001

    Review

    [Atherosclerosis--the role of nitric oxide].

    • D Caillaud, M Galinier, M Elbaz, D Carrié, J Puel, J M Fauvel, and J F Arnal.
    • INSERM U397 et Service de Cardiologie, CHRU Rangueil, Toulouse.
    • Presse Med. 2001 Jan 13; 30 (1): 41-4.

    AbstractATHEROSCLEROSIS: Currently regarded as a multifactorial disease, atherosclerosis involves several factor including: oxidized LDL, endothelial cells, macrophages, immune cells, vascular smooth muscle cells. The endothelium appears to play a key role through the production of vasomotor, antiaggregate and leukocyte antiadhesion molecules. NITRIC OXIDE: NO is one of the most important mediators of endothelial antiatherothrombotic functions. Loss of endothelial production, called "endothelial dysfunction", i.e. loss of endothelial vasorelaxing, antiaggregate and leukocyte antiadhesion properties, could lead to increased fatty streak formation and acute arterial events (thrombus formation, vascular spasm).

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