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- M Righini, H Bounameaux, and A Perrier.
- Division d'Angiologie et d'Hémostase, Hôpital Universitaire de Genève, 24, rue Micheli-du-Crest, 1211 Genève 14-Suisse.
- Presse Med. 2001 Dec 22; 30 (39-40 Pt 1): 1945-52.
AbstractFIBRIN BREAKDOWN PRODUCTS: D-dimers are protein substances resulting from the action of 3 enzymes, thrombin, factor XIII and plasmin, on the fibrinogen molecules. In the case of thrombosis, all these enzymatic reactions are activated, explaining the increase in D-dimer levels induced. The notion of a threshold is only significant for a given test; the 500 micrograms/L threshold is widely used for tests relying on ELISA methods (enzyme-linked immunosorbent assay). FROM A TECHNICAL POINT OF VIEW: The use of D-dimer ELISA in excluding pulmonary embolism is now well established. New quantitative tests with latex, based on a turbidimetric method, also appear interesting in this context. The latter is reliable, rapid, inexpensive, remarkably sensitive (97 to 100%) and widely available.
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