• Presse Med · Mar 2002

    [Treatment of anemia in chronic renal failure by a long-activing activator of erythropoiesis].

    • Pablo Ureña.
    • Service de Néphrologie-Dialyse, Clinique de l'Orangerie, 11, boulevard Anatole France, 93300 Aubervilliers, France. purenat@fr.inter.net
    • Presse Med. 2002 Mar 23; 31 (11): 505-14.

    AbstractTHE INTEREST AND LIMITS OF ERYTHROPOIETIN: Chronic renal failure (CRF) is often associated with anemia, mainly because of insufficient renal synthesis of erythropoietin (EPO). This observation led in the early 1980 to the cloning of the complementary DNA coding for the EPO molecule, the large-scale production of a recombinant human EPO (rHuEPO), and its large utilisation in clinical practice. More than a decade after this outstanding research progress, the use of rHuEPO has literally transformed the treatment of anemia of CRF. The efficacy of rHuEPO is dose-dependent and corrects the anemia in the majority of the patients. However, its relative short plasma half-live (4-8 hours) requires repeated injections of the drug, usually two to three times a week.

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