• Presse Med · Apr 2002

    Review

    [Ivermectin, a broad spectrum antiparasitic drug].

    • Annick Datry, Marc Thellier, Oussmane Alfa-Cissé, Martin Danis, and Eric Caumes.
    • Groupe Hospitalier Pitié-Salpêtrière, Paris.
    • Presse Med. 2002 Apr 6; 31 (13): 607-11.

    ActivityIvermectine, derived from beta avermectines, monocyclic lactones produced by Streptomyces avermitilis, is a potent oral microfilaricide used by veterinaries since 1981. The anti-filarial activity is two-fold: both microfilaricide and embryotoxic in female adults; it has no activity on the latter.IndicationsIvermectine is the treatment of choice in onchocercosis, induced by the nematode Onchocerca volvulus, and was included in the onchocercosis control program (programme de contrôle de l'onchocercose (OCP) in 1987. Ivermectine has also demonstrated efficacy on other filaries (Wuchereria bancrofti, Loa loa), in intestinal nematodes (Ascaris lumbricoïdes, Strongyloides stercoralis) and in parasite nematodes in man (larva migrans ankylosis).According To The Results Of Recent StudiesIts activity has been recently extended to ectoparasitosis: sarcoptes and pediculosis of the scalp.

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