• Patricia Adams-Graves, Alden B Daniels, Catherine R Womack, and Amado X Freire.
• Division of Hematology, Department of Medicine (PA-G), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biological Sciences (ABD), College of Arts and Sciences, University of Memphis, Memphis, Tennessee; and Department of Medicine (CRW) and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine (AXF), University of Tennessee Health Science Center, Memphis, Tennessee.
• Am. J. Med. Sci. 2014 Apr 1; 347 (4): 262266262-6.

ObjectiveTo describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD).Inclusion/Exclusion CriteriaAll SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded.Data CollectionDemographics, body mass index and SCD genotype.LaboratoryAlbumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria.Statistical AnalysesMean ± standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The χ test was used to analyze categorical variables; Student's t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95% confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P ≤ 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis.ResultsSeventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42% of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14%.ConclusionsA large proportion of adult AA men with SCD and Vit DD showed low BMD.

31 keywords...

hide…