• Yanmei Huan, Yiwei Qi, Weisheng Zhang, and Jianguo Chu.
• Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
• Medicine (Baltimore). 2017 Apr 1; 96 (15): e6603.

RationalePrimary bone lymphoma (PBL) is a rare malignant entity. There is a better survival of PBL than any other malignant bone tumors and extranodal lymphomas.Patient ConcernsWe report a rare case of PBL involving radius and tibia. The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented.DiagnosesRadiological imaging revealed a lytic destruction, periosteal reaction, and pathological fracture of radius and tibia with soft tissue mass. Surgical biopsy was performed, and the result of histopathological diagnosis was diffused large B-cell lymphoma (stage IV, group A).InterventionChemotherapy combined with radiotherapy was applied before curation.LessonsDue to its uncommon presentation, PBL should be taken into consideration if differential diagnosis from other bone tumors is necessary in clinic.

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