• Medicine · Nov 2017

    Case Reports

    Crizotinib resistance overcome by ceritinib in an ALK-positive non-small cell lung cancer patient with brain metastases: A case report.

    • Zhouyu Zhu and Ying Chai.
    • Department of Thoracic Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    • Medicine (Baltimore). 2017 Nov 1; 96 (45): e8652.

    RationaleThe treatment of non-small cell lung cancer (NSCLC) has now changed dramatically in recent years and anaplastic lymphoma receptor tyrosine kinase (ALK) inhibitors are developing rapidly.Patient ConcernsHere we reported a 57-year-old ALK-positive NSCLC man with brain metastases.DiagnosesA case of lung adenocarcinoma with brain metastases.InterventionsCrizotinib was administered orally at a dose of 250mg twice a day until the brain metastases were found. Treatment with orally administered ceritinib at a dose of 450mg/d was initiated after crizotinib treatment.OutcomesThe patient is currently receiving maintenance ceritinib treatment, with no evidence of extracranial or intracranial tumor progression for 25 months.LessonsCeritinib may be a good choice for ALK-positive NSCLC patients with brain metastases who acquire resistance to crizotinib.

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