• Meredith C McCormack, Nadia N Hansel, Elizabeth C Matsui, Gregory B Diette, Patrick N Breysse, Daniel B Jamieson, Andrew Belli, Eric Peng, Simon Pierre-Louis, and Jean Curtin-Brosnan.
• Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
• Am. J. Respir. Crit. Care Med.. 2013 Jul 15;188(2):187-92.

RationaleChronic obstructive pulmonary disease (COPD) guidelines make no recommendations for allergy diagnosis or treatment.ObjectivesTo determine whether an allergic phenotype contributes to respiratory symptoms and exacerbations in patients with COPD.MethodsTwo separate cohorts were analyzed: National Health and Nutrition Survey III (NHANES III) and the COPD and domestic endotoxin (CODE) cohort. Subjects from NHANES III with COPD (n = 1,381) defined as age > 40 years, history of smoking, FEV1/FVC < 0.70, and no diagnosis of asthma were identified. The presence of an allergic phenotype (n = 296) was defined as self-reported doctor diagnosed hay fever or allergic upper respiratory symptoms. In CODE, former smokers with COPD (n = 77) were evaluated for allergic sensitization defined as a detectable specific IgE to perennial allergens. Bivariate and multivariate models were used to determine whether an allergic phenotype was associated with respiratory symptoms and exacerbations.Measurements And Main ResultsIn NHANES III, multivariate analysis revealed that individuals with allergic phenotype were more likely to wheeze (odds ratio [OR], 2.1; P < 0.01), to have chronic cough (OR, 1.9; P = 0.01) and chronic phlegm (OR, 1.5; P < 0.05), and to have increased risk of COPD exacerbation requiring an acute doctor visit (OR, 1.7; P = 0.04). In the CODE cohort, multivariate analysis revealed that sensitized subjects reported more wheeze (OR, 5.91; P < 0.01), more nighttime awakening due to cough (OR, 4.20; P = 0.03), increased risk of COPD exacerbations requiring treatment with antibiotics (OR, 3.79; P = 0.02), and acute health visits (OR, 11.05; P < 0.01). An increasing number of sensitizations was associated with a higher risk for adverse health outcomes.ConclusionsAmong individuals with COPD, evidence of an allergic phenotype is associated with increased respiratory symptoms and risk of COPD exacerbations.

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