• Jia-Jia Zhou, Jin-Feng Xu, Xu-Ning Zheng, and Guo-Ping Peng.
• aDepartment of Neurology bDepartment of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
• Medicine (Baltimore). 2017 Nov 1; 96 (46): e8593.

RationaleAsympotamic syringomyelia accompanied with metastatic cerebellar and thoracic spinal intramedullary lymphoma is rare in clinical practice. If the intramedullary lymphoma is large enough, the patient will rapidly develop neurologic signs of spinal injury. The prognosis of this type of complication is always bad.Patient ConcernsRapid and correct diagnosis and treatment is important for metastatic extranodal lymphoma with B cell of origin.DiagnosesSyringomyelia accompanied with metastatic cerebellar and thoracic spinal intramedullary lymphoma.InterventionsThe patient was treated with a combination of systemic chemotherapy and focal radiotherapy and intrathecal therapy.OutcomesResolution of metastatic lymphoma was not continued after conservative medical management and the patient died finally due to multiple organ failure.LessonsSyringomyelia can develop due to the metastatic thoracic intramedullary lymphoma in patients with diffuse malignant large B cell lymphoma. Early and accurate diagnosis, anti-lymphoma treatment, and timely neurosurgical intervention may delay the development of the disease.

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