• Junjie Xiong, Selina Kwong Chian, Jiao Li, and Xubao Liu.
• aDepartment of Pancreatic Surgery bWest China School of Medicine cDepartment of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
• Medicine (Baltimore). 2017 Nov 1; 96 (46): e8726.

RationaleThe image-guided iodine-125 seed implantation has been widely used for a variety of tumors, including prostatic cancer, pulmonary cancer, hepatocellular carcinoma and pancreatic cancer. However, the clinical value of iodine-125 seed implantation for the treatment of pancreatic metastasis from hepatocellular carcinoma has not been reported. We presented the first case with ultrasound-guided iodine-125 seed implantation for this disease.Patient ConcernsWe presented the case of a 48-year-old man patient with primary hepatocellular carcinoma and pancreatic metastasis who was managed with ultrasound-guided iodine-125 seeds implantation.DiagnosesShe was diagnosed with synchronous pancreatic metastases from hepatocellular carcinoma.InterventionsPuncture biopsy and ultrasound-guided iodine-125 seeds implantation.OutcomesThe hepatic and pancreatic tumors were obviously reduced after 15 months. Moreover, the liver function test was mildly abnormal in glutamic-oxalacetic transaminase and glutamic-pyruvic transaminase.LessonsThe image-guided iodine-125 seeds implantation was an important therapeutic approache to unresectable hepatocellular carcinoma with pancreatic metastasis. However, more related cases should be reported for further evaluating the value of the way.

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