• Jae Jun Yang, Byungyoung Ryu, Ji Weon Moon, Taehyun Kim, and Sehan Park.
• Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Goyangsi, Gyeonggido, Republic of Korea.
• Spine. 2022 Jul 1; 47 (13): 944953944-953.

Study DesignRetrospective cohort study.ObjectiveThe aim of this study was to evaluate the incidence and clinical implications of graft morphologic changes in corticocancellous allografts used for anterior cervical discectomy and fusion (ACDF), such as graft resorption or fracture.Summary Of Background DataAlthough cortico-cancellous allograft is one of the most commonly used interbody spacer for ACDF, clinical implications of allograft resorption or fracture is unclear.MethodsOne-hundred and thirty-eight consecutive patients who underwent ACDF for degenerative cervical myelopathy or radiculopathy were retrospectively reviewed. Patients with allograft morphologic changes, including graft resorption and fracture (morphologic change group), were compared with patients without morphologic changes (unchanged group). Furthermore, operated segments with morphologic changes were compared with unchanged segments. Patient characteristics, cervical lordosis, segmental lordosis, fusion, subsidence, neck pain visual analogue scale (VAS), arm pain VAS, and neck disability index (NDi) scores were evaluated.ResultsNinety patients (149 segments) were included in the study. Allograft resorption or fracture was detected in 46 (51.1%) patients and 81 (54.3%) segments, respectively. The fusion rate of morphologic change segments was significantly lower than that of the unchanged segments (P < 0.001). Furthermore, segments with morphologic changes had significantly higher rates of subsidence compared to unchanged segments ( P < 0.001). Segmental lordosis at the final follow-up was significantly smaller in the morphologic change segments ( P < 0.001). Neck pain VAS, arm pain VAS, and NDI scores did not demonstrate significant intergroup differences.ConclusionCorticocancellous allograft demonstrated a high rate of graft morphologic change (54.3%). Graft resorption or fracture was associated with increased pseudarthrosis, subsidence, and decreased postoperative segmental lordosis; however, the clinical results were not significantly affected. Caution is needed when choosing to use corticocancellous allografts for ACDF due to the high rate of graft resorption or fracture and the negative implications of these risks.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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