Pulmonary arterial hypertension.

Medicina clinica · Jun 2022

Review

Pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is a rare disease characterized by adverse remodeling of the arterial tree leading to increased vascular resistance with subsequent increase in right ventricular afterload and eventual development of heart failure. The nonspecific clinical manifestations and lack of knowledge of pathology lead to a poor prognosis associated with delay in diagnosis and initiation of treatment. The most recent recommendations focus on optimizing the early differential diagnosis with other causes of pulmonary hypertension to initiate appropriate treatment based on the mortality risk estimation. In the last years, with the improvement in the diagnostic process, the emergence of new specific treatments, and the creation of specialized referral units for this pathology, the prognosis, and quality of life of patients with PAH have improved significantly.

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- Raquel Luna-López, Alicia Ruiz Martín, and Escribano SubíasPilarPUnidad de Hipertensión Pulmonar, Servicio de Cardiología, Hospital General Universitario 12 de Octubre, Madrid, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos II.
- Unidad de Hipertensión Pulmonar, Servicio de Cardiología, Hospital General Universitario 12 de Octubre, Madrid, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España; Instituto de Investigación Hospital 12 de Octubre, Madrid, España.
- Med Clin (Barc). 2022 Jun 24; 158 (12): 622-629.
AbstractPulmonary arterial hypertension (PAH) is a rare disease characterized by adverse remodeling of the arterial tree leading to increased vascular resistance with subsequent increase in right ventricular afterload and eventual development of heart failure. The nonspecific clinical manifestations and lack of knowledge of pathology lead to a poor prognosis associated with delay in diagnosis and initiation of treatment. The most recent recommendations focus on optimizing the early differential diagnosis with other causes of pulmonary hypertension to initiate appropriate treatment based on the mortality risk estimation. In the last years, with the improvement in the diagnostic process, the emergence of new specific treatments, and the creation of specialized referral units for this pathology, the prognosis, and quality of life of patients with PAH have improved significantly.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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Pulmonary arterial hypertension.

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