• Br J Surg · May 2022

    Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases.

    • Gudrun M W Bjørnelv, Zinajda Zolic-Karlsson, Svein Dueland, Pål-Dag Line, and Eline Aas.
    • Institute of Health and Society, Department of Health Management and Health Economics, University of Oslo, Oslo, Norway.
    • Br J Surg. 2022 May 16; 109 (6): 483485483-485.

    AbstractThis study estimated the cost-effectiveness of liver transplantation in patients with colorectal liver metastases confined to the liver with progressive disease, compared with alternative treatment options: TAS-102, regorafenib, or best supportive care. Using a mathematical simulation model, people’s life expectancy and healthcare costs over 25 years were estimated. Transplanted patients lived for 4.28 years, more than 3 years longer than those who received alternative treatment options. Despite this, the high cost of liver transplantation meant that this treatment was cost-effective only at high willingness-to-pay thresholds.

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