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- Ulises Aregueta-Robles, Oscar R Fajardo-Ramírez, Luis Villela, Janet A Gutiérrez-Uribe, José Hernández-Hernández, Rosa Del Carmen López-Sánchez, Sean-Patrick Scott, and Sergio Serna-Saldívar.
- Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, N.L., Mexico.
- Rev Invest Clin. 2018 Jan 1; 70 (1): 32-39.
BackgroundBlack bean (Phaseolus vulgaris L.) is a very common legume seed in Mexican diet. Flavonoids and crude extracts from different plants have been reported as effective agents for chemoprevention and cytotoxicity in several cancer cell lines. We investigated the effects of black bean hulls extract (BBE) and its flavonoid fraction (FF) on lymphoma cells.MethodsBBE and FF were characterized by high-performance liquid chromatography. Viability and flow cytometry assays were carried out. Finally, a mouse model was generated to test the in vivo effect of both fractions.ResultsBoth BBE and FF inhibited cell proliferation in a dose-dependent way. In addition, cells underwent apoptosis, and the cellular population at S-phase increased after exposure to these fractions. Furthermore, mice treated with BBE or FF increased the overall survival by 5 or 6 days, respectively, in comparison with a placebo group (p = 0.056).DiscussionBBE and FF had cytotoxic action by driving OCI-Ly7 cells into apoptosis as well as blocking progression to G2/M phase. In addition, BBE and FF treatments were effective in xenograft models.Copyright: © 2017 SecretarÍa de Salud.
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