• Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, Yumei Liu, Xijun Liu, Bo Sun, and Hulun Li.
• Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University Harbin, Heilongjiang 150081, P. R. China.
• Am. J. Chin. Med. 2022 Jan 1; 50 (3): 639-652.

AbstractAutoimmune diseases (AIDs) are conditions arising from abnormal immune reactions to autoantigens, which can be defined as the loss of immune tolerance to autoantigens, causing the production of autoantibodies and subsequent inflammation and tissue injury. The etiology of AIDs remains elusive, which may involve both genetic and environmental factors, such as diet, drugs, and infections. Despite rapid progress in the treatment of autoimmune diseases over the past few decades, there is still no approach that can cure AIDs. As an alternative approach, traditional Chinese medicine (TCM) such as acupuncture has been used in an attempt to treat AIDs including multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), and the results have proven to be quite promising, despite the fact that its mechanism is still not fully understood. In this review, the present knowledge regarding mechanisms of acupuncture in the treatment of AIDs has been summarized, and deeper insights will be provided in order to better understand how acupuncture may regulate immune responses during AIDs.

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