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Case Reports
Tubulointerstitial Nephritis after Using a Sodium-glucose Cotransporter 2 Inhibitor: A Case Report.
- Yusuke Konta, Eiichiro Saito, Koji Sato, Kyohei Furuta, Kenichiro Miyauchi, Akiko Furukawa, Hiroshi Sato, and Tae Yamamoto.
- Department of Internal Medicine, Sendai City Hospital, Japan.
- Intern. Med. 2022 Nov 1; 61 (21): 323932433239-3243.
AbstractWe herein report a case of acute kidney injury (AKI) due to tubulointerstitial nephritis (TIN) after starting empagliflozin in a diabetic patient. The patient developed stage 1 AKI with proteinuria and elevated tubulointerstitial markers. A renal biopsy showed acute TIN with lymphocytic infiltration into the interstitium. The patient's renal function improved after discontinuation of empagliflozin and steroid administration. Sodium-glucose cotransporter 2 (SGLT2) inhibitor-induced AKI has been reported, but the underlying mechanism remains unclear, potentially because few patients with SGLT2-inhibitor-induced AKI have undergone a renal biopsy. We report the present case in the hope that it will help clarify the mechanism.
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