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- Akira Ishimitsu, Akihiro Tojo, Jun Hirao, Shohei Yokoyama, Takehiro Ohira, Yoshiki Murayama, Toshihiko Ishimitsu, Dedong Kang, Kazuho Honda, Takashi Ehara, Kazuyuki Ishida, and Yoshihiko Ueda.
- Department of Nephrology & Hypertension, Dokkyo Medical University, Japan.
- Intern. Med. 2022 Jan 1; 61 (6): 871-876.
AbstractA 70-year-old woman with complaints of edema, general malaise, and hypotension was diagnosed with renal amyloidosis, and laser microdissection mass spectrometry revealed her amyloidosis to predominantly comprise the apolipoprotein A-IV type. The M-protein turned from negative to positive during the course, and a bone marrow biopsy showed smoldering myeloma. Treatment with bortezomib and dexamethasone failed to save her from heart failure six months after the onset. Western blotting of urine samples at the time of the renal biopsy showed that amyloid light-chain κ amyloidosis had been present since the onset. Unlike the myeloma, Congo red staining was positive in the plasma cells of the bone marrow.
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