• Jiequn Huang, Changzhi Liu, Ruiqiu Zhu, Yongpeng Su, Jingcheng Lin, Jianhai Lu, Shuchao Wen, and Liuer Zuo.
• Department of ICU, Shunde Hospital, Southern Medical University, Foshan Guangdong, China.
• Medicine (Baltimore). 2018 Jun 1; 97 (22): e10946.

RationaleWe report a man with amyopathic dermatomyositis (ADM) complicated by severe interstitial lung disease (ILD) received extracorporeal membrane oxygenation (ECMO) in combination with double filtration plasmapheresis (DFPP). This is the first report of the utility of ECMO in combination with DFPP in ADM related ILD in adults.Patient ConcernsA 48-year-old man who was previously healthy had a 2-month history of cough and shortness of breath, which aggravated in 5 days.DiagnosesAmyopathic dermatomyositis and complicated by severe interstitial lung disease.InterventionsECMO was giving when the patient suffered acute respiratory failure. Though corticosteroids was giving, primary disease was still developing with relapses of spontaneous pneumomediastinum and pneumothorax. Then, DFPP treatment was initiated.OutcomeAfter the treatments above, the patient's clinical condition improved with the reduction of bilateral interstitial infiltrates and improvement of lung compliance. Unfortunately, he discontinued the treatment because of the financial problem.LessonsWhen get a rapid progressive interstitial lung disease for no apparent reason, amyopathic dermatomyositis should be considered, especially with suspected skin lesions. ECMO, in combination with DFPP, should be considered as a supportive therapy and initiated early in patients in acute respiratory failure secondary to ADM-ILD. Prompt initiation of DFPP in dermatomyositis patients with ILD might help reduce the occurrence of spontaneous pneumomediastinum or pneumothorax.

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