• Clinics · Jul 2015

    Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome.

    • Selahattin Akyol, Mustafa Çörtük, Ahmet Oytun Baykan, Kemal Kiraz, Abdurrezzak Börekçi, Taner Şeker, Mustafa Gür, and Murat Çayli.
    • Department of Cardiology, Adana Numune Training and Research Hospital, Çukurova/Adana, Turkey.
    • Clinics (Sao Paulo). 2015 Jul 1; 70 (7): 481485481-5.

    ObjectiveObstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.MethodsWe prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI<15, (2) AHImid group: 1530.ResultsThe highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010).ConclusionThe MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.

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