• Oluwaseun Falade-Nwulia, Catalina Suarez-Cuervo, David R Nelson, Michael W Fried, Jodi B Segal, and Mark S Sulkowski.
• From Johns Hopkins University School of Medicine, Baltimore, Maryland; University of Florida, Gainesville, Florida; and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
• Ann. Intern. Med. 2017 May 2; 166 (9): 637648637-648.

BackgroundRapid improvements in hepatitis C virus (HCV) therapy have led to the approval of multiple oral direct-acting antiviral (DAA) regimens by the U.S. Food and Drug Administration (FDA) for treatment of chronic HCV infection.PurposeTo summarize published literature on the efficacy and safety of oral DAAs for treatment of persons with chronic HCV infection.Data SourcesMEDLINE and EMBASE from inception through 1 November 2016.Study Selection42 English-language studies from controlled and single-group registered clinical trials of adults with HCV infection that evaluated at least 8 weeks of an FDA-approved interferon-free HCV regimen that included at least 2 DAAs.Data ExtractionTwo investigators abstracted data on study design, patient characteristics, and virologic and safety outcomes sequentially and assessed quality independently.Data SynthesisSix DAA regimens showed high sustained virologic response (SVR) rates (>95%) in patients with HCV genotype 1 infection without cirrhosis, including those with HIV co-infection. Effective treatments for HCV genotype 3 infection are limited (2 DAA regimens). Patients with hepatic decompensation, particularly those with Child-Turcotte-Pugh class C disease, had lower SVR rates (78% to 87%) than other populations. The addition of ribavirin was associated with increased SVR rates for certain DAA regimens and patient groups. Overall rates of serious adverse events and treatment discontinuation were low (<10% in the general population); regimens that included ribavirin had more mild or moderate adverse events than those without.LimitationsTwenty-three studies had moderate risk of bias (10 were open-label single-group trials, 11 had limited information on concealment of the allocation scheme, and 5 had selective outcome reporting). All but 1 of the studies were industry-funded. Heterogeneity of interventions precluded pooling.ConclusionMultiple oral DAA regimens show high rates of safety, tolerability, and efficacy for treatment of HCV genotype 1 infection, particularly among persons without cirrhosis.Primary Funding SourcePatient-Centered Outcomes Research Institute. (PROSPERO: CRD42014009711).

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