• Eur. J. Intern. Med. · Nov 2016

    Review

    Aging of the endocrine system and its potential impact on sarcopenia.

    • Giovanni Vitale, Matteo Cesari, and Daniela Mari.
    • Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy; Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Cusano Milanino (MI), Italy. Electronic address: giovanni.vitale@unimi.it.
    • Eur. J. Intern. Med. 2016 Nov 1; 35: 10-15.

    AbstractSarcopenia, occurring as a primary consequence of aging, is a progressive generalized decline of skeletal muscle mass, strength and function. The pathophysiology of sarcopenia is complex and multifactorial. One major cause of muscle mass and strength loss with aging appears to be the alteration in hormonal networks involved in the inflammatory processes, muscle regeneration and protein synthesis. This review describes the recent findings concerning the role of the aging on the endocrine system in the development of sarcopenia. We also report the benefits and safety of hormone replacement therapy in elderly subjects and discuss future perspectives in the therapy and prevention of skeletal muscle aging.Copyright © 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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