• Pablo Romero-Morelos, Arizbett Uribe-Jiménez, Cindy Bandala, Albros Poot-Vélez, Nora Ornelas-Corral, Miriam Rodríguez-Esquivel, Mariana Valdespino-Zavala, Keiko Taniguchi, Daniel Marrero-Rodríguez, Ricardo López-Romero, and Mauricio Salcedo.
• Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Unidad Médica de Alta Especialidad, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
• Med Clin (Barc). 2017 Oct 11; 149 (7): 287-292.

Background And ObjetiveHuman papilloma virus (HPV) is one of the main risk factors associated with the development of cervical cancer and its precursor lesions. It has been reported that HPV16 and 18 types cover approximately 70% of cervical cancer worldwide; however, significant variation in percentages of HPV infections could be related to specific populations.Materials And MethodsPurified DNA of 67 cervical samples were analyzed by Linear Array® HPV genotyping kit. These analyzed samples correspond to 19 cervical tumors, 15 high-grade squamous intraepithelial lesions, 20 low-grade squamous intraepithelial lesions, and 13 cervical samples without injury were studied, all of them previously diagnosed.ResultsIn general, 16 different HPV types were found with differences in their frequencies, cervical invasive cancer being the richest in HPV sequences, followed by the low-grade squamous intraepithelial lesions and then high-grade lesions. HPV16 was the most frequently distributed type in neoplastic lesions of the cervix, followed by the HPV52, suggesting viral type variability, probably associated to the geographical region studied.ConclusionsThe results could indicate variability in HPV presence in Mexico, underlining the important role for HPV52 among others in the Mexican population. This would also potentially have an impact on the current anti-HPV vaccination schemes.Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

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