• Clin Med (Lond) · Mar 2022

    Case Reports

    Lessons of the month 2: A case of inappropriate drug-drug interaction in kidney transplant.

    • Min-Hui Tan, Seow-Yeing Yee, and Rosnawati Yahya.
    • consultant nephrologist, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia tanminhui83@yahoo.com.
    • Clin Med (Lond). 2022 Mar 1; 22 (2): 169171169-171.

    AbstractCarbamazepine remains a first-line antiepileptic medication for the treatment of partial seizures. Despite its widespread use, carbamazepine has significant neurotoxicity and hypersensitivity reactions. We report a case of a patient post-kidney transplant who was on regular carbamazepine for childhood epilepsy and developed nystagmus, diplopia and a broad-base gait after receiving diltiazem. Understanding of the interaction between diltiazem and carbamazepine is necessary to prevent the neurotoxic effects.© Royal College of Physicians 2022. All rights reserved.

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