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- Jiyu Li, Junming Du, Lijuan Sun, Jianwen Liu, and Zhiwei Quan.
- Institute of Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, China. leejiyu@sina.com
- Am. J. Chin. Med. 2010 Jan 1; 38 (1): 127-42.
AbstractIn order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.
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