• Somayeh Makvandi, Mitra Tadayon, and Mohammadreza Abbaspour.
• Department of Pharmaceutics, Nanotechnology Research Center and School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd., Ahvaz, Iran.
• Croat. Med. J. 2011 Apr 15; 52 (2): 159-63.

AimTo determine the effects of hyoscine-N-butyl bromide (HBB) rectal suppository on labor progress in primigravid women.MethodsA randomized double-blind placebo-controlled clinical trial was carried out on 130 primigravid women admitted for spontaneous labor. The women were recruited based on the inclusion and exclusion criteria and randomized into the experimental (n=65) and control group (n=65). In the beginning of the active phase of labor, 20 mg of HBB rectal suppository was administered to the experimental group, while a placebo suppository was administered to the control group. Cervical dilatation and duration of active phase and second stage of labor were recorded.ResultsThe rate of cervical dilatation was 2.6 cm/h in the experimental and 1.5 cm/h in the control group (P<0.001). The active phase and the second stage of labor were significantly shorter in the experimental group (P=0.001 and P<0.001, respectively). There was no significant difference between the two groups in the fetal heart rate, maternal pulse rate, blood pressure, and the APGAR score 1 and 5 minutes after birth.ConclusionUse of HBB rectal suppository in the active management of labor can shorten both the active phase and second stage of labor without significant side-effects.

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