• J Chin Med Assoc · Mar 2012

    Shrinkage of head and neck cancer specimens after formalin fixation.

    • Chih-Hon Chen, Meng-Yu Hsu, Rong-San Jiang, Sheng-Heng Wu, Fun-Jou Chen, and Shih-An Liu.
    • Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
    • J Chin Med Assoc. 2012 Mar 1; 75 (3): 109-13.

    BackgroundWe conducted this study to investigate whether formalin fixation is associated with the shrinkage of head and neck cancer specimens.MethodsPatients scheduled to undergo operation were eligible for enrollment. Fresh specimens were measured immediately in the operating room, and the measurements were repeated after formalin fixation.ResultsA total of 100 specimens were collected. Nearly half of them were obtained from the oral cavity (n=49), and a large majority were squamous cell carcinoma (n=69). The average decreases in length, width, and depth after formalin fixation were 1.50mm (4.40%), 1.52 mm (6.18%), and 0.67 mm (4.10%), respectively. There was no significant difference in the shrinkage percentage associated with gender, age, tumor site, tumor size, or histology.ConclusionWe found that head and neck cancer specimens shrink after formalin fixation. Therefore, we recommend that the specimen be measured immediately in order to avoid the underestimation of tumor size.Copyright © 2012. Published by Elsevier B.V.

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