• Leandro Fórnias Machado Rezende, Thiago Hérick Sá, Grégore Iven Mielke, ViscondiJuliana Yukari KodairaJYKDepartment of Preventive Medicine, University of Sao Paulo School of Medicine, São Paulo, Brazil; Medical Investigation Laboratories (LIM38), Clinics Hospital of Faculty of Medicine, University of São Paulo, São Paulo, Bra, Juan Pablo Rey-López, and GarciaLeandro Martin TotaroLMTDepartment of Nutrition, University of Sao Paulo School of Public Health, São Paulo, Brazil. Electronic address: lerezende@usp.br..
• Department of Preventive Medicine, University of Sao Paulo School of Medicine, São Paulo, Brazil.
• Am J Prev Med. 2016 Aug 1; 51 (2): 253-263.

IntroductionRecent studies have shown that sitting time is associated with increased risk of all-cause mortality, independent of moderate to vigorous physical activity. Less is known about the population-attributable fraction for all-cause mortality associated with sitting time, and the gains in life expectancy related to the elimination of this risk factor.MethodsIn November 2015, data were gathered from one published meta-analysis, 54 adult surveys on sitting time distribution (from 2002 to 2011), in conjunction with national statistics on population size, life table, and overall deaths. Population-attributable fraction for all-cause mortality associated with sitting time >3 hours/day was estimated for each country, WHO regions, and worldwide. Gains in life expectancy related to the elimination of sitting time >3 hours/day was estimated using life table analysis.ResultsSitting time was responsible for 3.8% of all-cause mortality (about 433,000 deaths/year) among those 54 countries. All-cause mortality due to sitting time was higher in the countries from the Western Pacific region, followed by European, Eastern Mediterranean, American, and Southeast Asian countries. Eliminating sitting time would increase life expectancy by 0.20 years in those countries.ConclusionsAssuming that the effect of sitting time on all-cause mortality risk is independent of physical activity, reducing sitting time plays an important role in active lifestyle promotion, which is an important aspect of premature mortality prevention worldwide.Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

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