• Marco Antonio Avila-Vergara, Felipe de Jesús Peraza-Garay, Noemí Meraz-Cruz, Cesar Hernandez-Guerrero, Berenice Palacios-Gonzalez, and Felipe Vadillo-Ortega.
• Department of Obstetrics and Gynecology, Hospital Regional No. 1, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
• Rev Invest Clin. 2018 Jan 1; 70 (2): 96-102.

BackgroundIt has been proposed that abnormal modulation of inflammatory response is involved in the physiopathology of idiopathic recurrent spontaneous abortion (iRSA). Factors that may participate in this process include the genetic background such as carrying specific polymorphisms of genes with functional effects.ObjectiveThe objective is to study the association between iRSA and the frequency of intron-2 variable number tandem repeat-polymorphisms of interleukin-1 receptor antagonist gene (IL1RN).MethodsWe conducted a case-control study including 108 women with iRSA and 103 controls. Five allelic variants of IL1RN were determined by polymerase chain reaction (PCR) product length analysis.ResultsThe most frequent IL1RN allele in this population was IL1RN*1, which was present in 78% of cases and 94% of controls, and allele IL1RN*2, in 45 (20.8%) cases and 12 (5.8%) controls. Allele IL1RN*2 was significantly associated with iRSA (odds ratio = 4.28, 95% confidence interval 2.2-8.4; p = 0.000).ConclusionCarrying allele IL1RN*2 had a strong association with iRSA in Mexican women. This polymorphism codifies for a low-function protein, which may allow for increased activity of IL-1 pro-inflammatory axis in iRSA.Copyright: © 2017 SecretarÍa de Salud.

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