• Rev Invest Clin · May 2022

    Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?

    • Denise Clavijo-Cornejo, Alberto López-Reyes, Esteban Cruz-Arenas, Leonor Jacobo-Albavera, Daniel Rivera-Tlaltzicapa, Adriana Francisco-Balderas, Mayra Domínguez-Pérez, Pablo Romero-Morelos, Janitzia Vázquez-Mellado, Luis H Silveira, Carlos Pineda, Gabriela Martínez-Nava, and Marwin Gutierrez.
    • Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
    • Rev Invest Clin. 2022 May 2; 74 (3): 147-155.

    BackgroundThe inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release.ObjectiveThe objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility.MethodsMexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs.ResultsWe found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs.ConclusionOur findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.

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