• A&A practice · Mar 2022

    Case Reports

    Bilateral Sphenopalatine Ganglion Block With Liposomal Bupivacaine Followed by Severe Hypertension: A Case Report.

    • Steven Havlik, Kumiko Chino, Joshua Lebenson, Pierre Cagniart, Erin Hamersley, and Matthew Haldeman.
    • From the University of Utah Medical School, Salt Lake City, Utah.
    • A A Pract. 2022 Mar 23; 16 (3): e01574e01574.

    AbstractWe reviewed a case of bilateral sphenopalatine ganglion (SPG) blockade with liposomal bupivacaine for sinus surgery. The case was complicated by severe postoperative hypertension refractory to antihypertensives and needing intensive care unit (ICU) admission. While SPG blockade has been used to treat headaches and provide perioperative analgesia, this complication and a possible mechanism have not been described. We discuss how local anesthetic spread beyond the SPG may have caused prolonged parasympathetic blockade and hypertension. Before approved indications are established, we recommend avoiding the use of liposomal bupivacaine in off-label settings when the function of bilateral autonomic structures could be affected.Copyright © 2022 International Anesthesia Research Society.

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