• Yader Sandoval, Stephen W Smith, and Fred S Apple.
• Division of Cardiology, Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn; Minneapolis Heart Institute, Abbott-Northwestern Hospital, Minn. Electronic address: yader.sandoval@hcmed.org.
• Am. J. Med. 2016 Apr 1; 129 (4): 354-65.

AbstractDespite its wide utilization and central role in the evaluation of patients with potential ischemic symptoms, misconceptions and confusion about cardiac troponin (cTn) prevail. The implementation of high-sensitivity (hs) cTn assays in clinical practice has multiple potential advantages provided there is an education process tied to the introduction of these assays that emphasizes the appropriate utilization of the test. Several diagnostic strategies have been explored with hs-cTn assays, including the use of undetectable values, accelerated serial hs-cTn sampling, hs-cTn measurements in combination with a clinical-risk score, and the use of a single hs-cTn measurement with a concentration threshold tailored to meet a clinical need. In this document we discuss basic concepts that should facilitate the integration of hs-cTn assays into clinical care in years to come. Copyright © 2016 Elsevier Inc. All rights reserved.

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