• J. Korean Med. Sci. · Aug 2015

    Multicenter Study Clinical Trial

    Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients.

    • Ga-Young Ban, Young-Min Ye, Yunhwan Lee, Jeong-Eun Kim, Young-Hee Nam, Soo-Keol Lee, Joo-Hee Kim, Ki-Suck Jung, Sang-Ha Kim, Hae-Sim Park, and Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group.
    • Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
    • J. Korean Med. Sci. 2015 Aug 1; 30 (8): 1042-7.

    AbstractThe geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients.

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