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- Ryohei Ono, Yuta Iwai, Tatsuro Yamazaki, Hidehisa Takahashi, Yasuhiko Hori, Kenichi Fukushima, and Takashi Saotome.
- Department of Cardiology, Matsudo City General Hospital, Japan.
- Intern. Med. 2022 Oct 1; 61 (19): 2973-2979.
AbstractImmune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patients with myositis and/or myocarditis. However, the clinical relationship between positive anti-striated antibodies and irAEs of ICIs remains unknown. We herein report a case of nivolumab-induced myositis and myocarditis with positive anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody in a patient with non-small-cell lung cancer. We also review reported cases of positive anti-striated antibodies related to irAEs of ICIs.
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