• Internal medicine · May 2022

    Review Case Reports

    Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review.

    • Takuto Shonai, Fumihiko Kimura, and Junichi Watanabe.
    • Department of Hematology, TMG Asaka Medical Center, Japan.
    • Intern. Med. 2022 May 15; 61 (10): 1581-1585.

    AbstractWe herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP.

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