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- Pedro Câmara Pestana, Carla Ferreira, Ana Luísa Santos, Joana Jerónimo, and Licínia Ganança.
- Department of Psychiatry and Mental Health. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa; Department of Psychiatry. Faculty of Medicine. University of Lisbon. Lisboa. Portugal.
- Acta Medica Port. 2022 Mar 2; 35 (3): 216-218.
AbstractSibutramine is a serotonin-norepinephrine-dopamine reuptake inhibitor, initially developed as a potential antidepressant and later approved for the management of obesity. Sibutramine use is also associated with psychiatric symptoms, namely mania, panic attacks, and, less frequently, psychosis. We report the case of a 32-year-old man, admitted to our hospital due to a suicide attempt in the context of sibutramine-associated psychosis. The symptoms remitted completely after discontinuation of sibutramine and a brief period of antipsychotic medication. The aim of this manuscript is to highlight the importance of the recognition of sibutramine-associated psychosis, to discuss the possible pathophysiology and the proper clinical and therapeutic management.
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