• Medicine · Dec 2015

    Observational Study

    Hemophagocytic Lymphohistiocytosis in Intensive Care Unit: A 71-Case Strobe-Compliant Retrospective Study.

    • Thomas Barba, Delphine Maucort-Boulch, Jean Iwaz, Julien Bohé, Jacques Ninet, Arnaud Hot, Jean-Christophe Lega, Claude Guérin, Laurent Argaud, Christiane Broussolle, Yvan Jamilloux, Jean-Christophe Richard, and Pascal Sève.
    • From the Hospices Civils de Lyon, Department of Internal Medicine, Croix-Rousse University Hospital, Lyon; Université Lyon I, Villeurbanne (TB, CB, YJ, PS); Hospices Civils de Lyon, Service de Biostatistique, Lyon; CNRS UMR 5558, Equipe Biostatistique-Santé, Pierre-Bénite; Université Lyon I, Villeurbanne (DM-B, JI); Hospices Civils de Lyon, Intensive Care Unit, Centre Hospitalier Lyon Sud, Pierre-Bénite; Université Lyon I, Villeurbanne (JB); Hospices Civils de Lyon, Department of Internal Medicine, Edouard Herriot University Hospital, Lyon; Université Lyon I (JN, AH); Hospices Civils de Lyon, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre-Bénite; Université Lyon I (JCL); Hospices Civils de Lyon, Intensive Care Unit, Croix-Rousse University Hospital, Lyon; Université Lyon I, Villeurbanne (CG, JCR); and Hospices Civils de Lyon, Intensive Care Unit, Edouard Herriot University Hospital, Lyon; Université Lyon I, Villeurbanne, France (LA).
    • Medicine (Baltimore). 2015 Dec 1; 94 (51): e2318.

    AbstractHemophagocytic lymphohistiocytosis (HLH) is a critical condition that may lead to organ failure and early death. The aim of this retrospective observational study was to describe a cohort of HLH patients admitted to intensive care unit (ICU) and investigate the risk factors of early death.A positive HLH diagnosis was defined by an HScore ≥ 169. Univariate and multivariate analyses were carried out to investigate hospital and 28-day mortality risk factors. Between January 2002 and July 2014, 71 HLH cases were seen at our institution.The overall 28-day mortality (start at ICU admission) and hospital mortality were 38% and 68%, respectively. The factors associated with increased 28-day mortality were the sequential organ failure assessment score at ICU admission (P < .001) and advance in age (P = 0.03). The factors associated with increased hospital mortality were a high sequential organ failure assessment score at ICU admission (P < 0.01), advance in age (P = 0.04), and the presence of lymphoma-related HLH or HLH of unknown origin (P < 0.01).Organ failure overtops the classical early-death risk factors in adult ICU-admitted HLH patients. This failure and the subsequent early death may be prevented by timely specific cytotoxic therapies and the control of the underlying disease.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…