• Jun-Ke Wang, Yan-Wen Jin, Hai-Jie Hu, Parbatraj Regmi, Wen-Jie Ma, Qin Yang, Fei Liu, Cong-Dun Ran, Fei Su, Er-Liang Zheng, and Fu-Yu Li.
• Department of Biliary Surgery Department of Pathology Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
• Medicine (Baltimore). 2017 Dec 1; 96 (51): e9416.

RationalLymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare variant of hepatocellular carcinoma (HCC). To date, few cases have been reported in the literature, and almost no report in analyzing the different features of LEL-HCC.Patient ConcernsWe describe a 37-year-old female patient with a 32 × 30 mm mass in the right liver.InterventionsComplete surgical resection of the lesion was performed.DiagnosesHistopathological examination of the resected tumor revealed undifferentiated HCC cells with significant lymphocytes infiltration. Immunohistochemically, the tumor cells were positive for AFP (alpha fetoprotein), hepatocyte, CK8, and glypican-3. The patient was diagnosed with LEL-HCC.OutcomesThe patient had a favorable clinical outcome, and was free from tumor recurrence after a 52-months follow-up.LessonsOur case was the youngest patient of all the reported cases, and the third case who was infected with both hepatitis B virus (HBV) and hepatitis C virus (HCV). LEL-HCC is a rare variant of HCC, with a relatively favorable prognosis. Further research recruiting more patients is required to determine the accurate causes and mechanism of LEL-HCC.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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