• Medicina clinica · Sep 2015

    Observational Study

    [Quality control of oral anticoagulant therapy in Primary Care in Madrid City, Spain: CHRONOS-TAO study].

    • Alonso RocaRafaelRCentro de Salud Griñón, Área Sur, Madrid, España. Electronic address: alonsorocarafael@gmail.com., Carmen Arlene Figueroa Guerrero, Victoria Mainar de Paz, M Paz Arribas García, Luis Sánchez Perruca, Ricardo Rodríguez Barrientos, Mariano Casado López, and Ana M Pedraza Flechas.
    • Centro de Salud Griñón, Área Sur, Madrid, España. Electronic address: alonsorocarafael@gmail.com.
    • Med Clin (Barc). 2015 Sep 7; 145 (5): 192-7.

    ObjectivesTo determine quality control of patients with oral anticoagulant treatment recruited in Primary Care (PC) using the Rosendaal method to estimate time in therapeutic range (TTR) and comparing it with fraction of international normalized ratio (INR) in range and cross-sectional analysis (last INR registred).Material And MethodA retrospective observational study based on electronic medical record in routine clinical practice.SettingPC centers (262) in Madrid. We included all patients with acenocumarol treatment, with an INR therapeutic range established between 2 and 3. We excluded patients with valvular pathology and disrupted clinical follow up in PC (<3 INR determinations in the studied period, a period of>90 days or ≥ 3 periods of>60 days between 2 determinations). The final population was 49,312 patients. The variables considered were all INR values and their respective dates. TTR was calculated by the 3 methods above mentioned. We considered "therapeutic range" INR between 2-3 and "adjusted range" INR between 1.8-3.2. Optimal control for each patient was considered TTR>60%.ResultsBy using Rosendaal method, TTR was 66.8% (81.7% adjusted), with a percentage of total INR in range was 58.8% (66.5% adjusted), and, with the cross-sectional analysis, it was 70.5% (76.8% adjusted). Mean TTR was 65% (standard deviation 20.3), and the percentage of patients with TTR>60% was 63.3% (88.1% adjusted).ConclusionThe quality control of patients with oral anticoagulants in PC in Madrid is acceptable, similar or higher to other studies and pivotal trials of new anticoagulants. Compared to the Rosendaal method, total fraction of INR underestimates quality control, and cross-sectional analysis slightly overestimates it.Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

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