• Int J Med Sci · Jan 2013

    Thyroid-stimulating hormone is significantly associated with bone health status in men.

    • Kok-Yong Chin, Soelaiman Ima-Nirwana, Isa Naina Mohamed, Amilia Aminuddin, Mohamad Hanapi Johari, and NgahWan Zurinah WanWZ.
    • Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
    • Int J Med Sci. 2013 Jan 1; 10 (7): 857-63.

    Background And AimRecent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men.MethodsThis cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) levels.ResultsAll subjects had FT3 and FT4 levels within the in-house reference range and 13 subjects had lower than normal TSH levels. The results revealed that the SOS value of subjects was significantly associated with TSH after multiple adjustments (p<0.05). When subjects were divided into quintiles according to their TSH levels, the difference of SOS between men with low-normal TSH and high-normal TSH contributed significantly to the association between TSH and bone health status (p<0.05). The significance of the association persisted with the inclusion and exclusion of subclinical hyperthyroid subjects.ConclusionsThere was a significant association between TSH levels and bone health status in men as assessed by quantitative ultrasound. This age-independent association between TSH and SOS might explain some of the individual variation of bone health status in men.

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