• Hoda Ranjbar, Maryam Radahmadi, Hojjatallah Alaei, Parham Reisi, and Sara Karimi.
• Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
• Turk J Med Sci. 2016 Dec 20; 46 (6): 1915-1925.

Background/AimThe basolateral amygdala (BLA) modulates memory for emotional events and is involved in both stress and memory. This study investigated different durations of stress and the role of BLA on serum corticosterone level and spatial and cognitive memory.Materials And MethodsDifferent durations of stress (acute, mid, and chronic stress), with and without BLA lesion were induced in rats by 6 h/day restraint stress for 1, 7, and 21 days. Memory functions were evaluated by novel object recognition (NOR) and object location test (OLT).ResultsThe OLT findings showed locomotor activity and spatial memory slightly decreased with different durations of stress. The NOR findings significantly showed locomotor activity impairment in different durations of stress. Cognitive memory deficit was observed in mid stress. The corticosterone level significantly increased in the mid and chronic stress groups. Moreover, the mid stress was the strongest stress condition. There is a possibility that different stress durations act by different mechanisms. The recognition of a novel location decreased in all lesion groups. It was more severe in the NOR. The BLA lesion significantly decreased corticosterone level in the mid and chronic stress groups compared to similar groups without lesion.ConclusionThe BLA lesion caused more damage to cognitive than spatial memory in stressed groups.

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