• Cody A Rutledge, Brett A Kaufman, Cameron Dezfulian, and Jonathan Elmer.
• Division of Cardiology, Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: rutledca@pitt.edu.
• Resuscitation. 2022 May 1; 174: 424642-46.

IntroductionMetformin is a first-line diabetic therapy that improves survival in a wide number of ischemic pathologies. We tested the association of metformin with markers of cardiac and renal injury in diabetic post-arrest patients.MethodsWe performed a retrospective analysis of clinical outcomes in diabetic cardiac arrest patients with and without metformin therapy at a single academic medical center. We used generalized linear models to test the independent association of metformin, insulin, and other hypoglycemic agents with peak 24-hour serum creatinine and peak 24-hour serum troponin.ResultsMetformin prescription at the time of SCA was independently associated with lower 24-hour peak serum troponin and lower 24-hour peak serum creatinine when compared to non-metformin patients.ConclusionMetformin pretreatment may offer cardiac and renal protection for diabetic patients during sudden cardiac arrest.Copyright © 2022 Elsevier B.V. All rights reserved.

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