• Jae Kyun Park, So-Yeon Ahn, Su Hee Seok, Eun Mi Chang, Ji Won Kim, In Pyung Kwak, and Woo Sik Lee.
• Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University, Seoul, Korea.
• J. Korean Med. Sci. 2022 Mar 28; 37 (12): e96.

BackgroundThe single vitrified-warmed blastocyst transfer (SVBT) cycle has been increasingly utilized for assisted reproductive technology. Women of advanced maternal age (AMA) comprise a significant portion of patients who have undergone 'freeze-all' cycles. This study investigated the association between the post-warming extended culture duration and pregnancy outcomes in patients of AMA.MethodsThis retrospective cohort study analyzed the outcomes of 697 SVBT cycles between January 2016 and December 2017. The cycles were divided into 3 groups based on the age of the female partners: group I: < 35 years (n = 407), group II: 35-37 years (n = 176); and group III, 38-40 years (n = 114). Data are shown as the mean ± standard error of the mean. Data were analyzed using one-way ANOVA followed by Duncan's multiple range test. Statistical significance was set at P < 0.001.ResultsThe blastocyst rate, clinical pregnancy rate, and live birth rate (LBR) was significantly lower in the AMA groups. However, there were no significant differences in LBR in the transfer between the AMA and younger groups according to blastocyst morphology and post-warming extended culture duration.ConclusionPost-warming extended culture of blastocysts is not harmful to patients of AMA. It could be a useful parameter in clinical counseling and decision making for fertility treatments.© 2022 The Korean Academy of Medical Sciences.

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